TP Atlas

TP Atlas is a comprehensive "Targeted Proteins Research achievements database" in which you can access a variety of information on the target proteins, their structures, published papers and press release by navigating the network diagram drawn by Cell Illustrator for each TP Research project. It covers all 35 TP projects ranging from signal transduction networks to enzymatic reaction pathways in the three fields of fundamental biology, medicine/pharmacology and food/environment. (Cell Illustrator is a pathway drawing software developed by Prof. Satoru Miyano and his colleagues at the U. Tokyo)

Fundamental Biology

• FBA1 Structural and functional studies of bacterial type Ⅲ and type Ⅳ protein export systems
• FBA2 Structural basis for dynamic formation and mechanistic actions of huge and complicated proteolytic machinery
• FBA3 Structural basis of Atg proteins essential for autophagy
• FBA4 Structural biology of transcription factors and histone modification factors
• FBA5 Structure and function of voltage-sensor domain proteins
• FBA6 Structure-function analysis of protein complexes that regulate vesicular traffic
• FBA7 Structural studies of the cell-cell junctional proteins
• FBA8 Mechanism underlying selective activation of NF-kB via linear polyubiquitination
• FBB1 Structural Basis of Sensor System for Cytoprotective Gene Expression Responding to Carcinogens and Oxidative Stress
• FBB2 Solid-state NMR investigation on functional and irregular structures of H⁺-ATPsynthase Fo
• FBB3 3D structural and functional analyses for elucidation of the mechanism of mitochondrial respiration
• FBB4 Towards structure-based design of novel inhibitors for V -ATPase
• FBB5 Elucidation of the mechanism of high-order cellular functions achieved by non-coding RNAs

Medicine/Pharmacology

• MPA1 Structural analysis of molecules related to the innate immune system
• MPA2 Drug discovery-oriented analysis for structure and function of DOCK2 signaling molecules
• MPA3 Study on reactive oxygen-producing systems involved in neural cell death and structure-based discovery of their inhibitors
• MPA4 Structural analysis of γ-secretase complex for the development of the treatment for Alzheimer's disease
• MPA5 Development of anti-trypanosome drugs targeting nucleic acids and red-ox regulatory pathway
• MPA6 Structure-based functional analyses and development of drug intervention in metabolic syndrome and diabetes- AdipoR/AMPK/ACC as key targets
• MPB1 Structural and Functional Analysis of a Molecular Target FROUNT for Drug Discovery
• MPB2 Development of new compounds for fibrosis therapy
• MPB3 Structure and drug development of NPP family members involved in cancer and various diseases
• MPB4 Structural and functional analysis of semaphorins and their receptors

Food/Environment

• FEA1 Structural and functional analyses of signaling proteins for insect control
• FEA2 Structure-based functional analysis of key enzymes that can be applied to production of antibiotics and other useful compounds
• FEA3 Structural and functional analyses of transcriptional regulatory proteins useful for breading of drought and heat stress tolerant crops
• FEA4 Structural and functional analyses of regulatory proteins in plant growth and stress resistance, that is useful for improvement of the stress-resistant crop
• FEA5 Structural biology on efflux transport machineries to understand multi-drug resistance
• FEA6 Study on chemical biology of the deacetylase SIRT3 involved in the regulation of an energy metabolism
• FEB1 Structural and functional analyses of the rodent ESP family
• FEB2 Structural and functional analysis of taste receptors applicable to development of new taste substances and taste evaluation systems
• FEB3 Structural biology of bacterial super-biosystem for import and degradation of polysaccharides and its application to food and environmental areas
• FEB4 Structual and functional analyses of enzymes involved in a new carbon dioxide fixation system and their functional improvement
• FEB5 Structure-function analyses and improvement of useful enzymes for chiral compound prodcution
• FEB6 Structure and function of environmentally-responsive proteins

Curators

• Name:　Sei Miyamoto, Yasumasa Shigemoto, Takeshi Konno, Hisashi Mizutani, Takao Iwayanagi and Hideaki Sugawara

• Affiliation: Information Platform in Targeted Proteins Research Program Research Organization of Information and Systems

• Contact:

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